How do I dose ReFacto? Your doctor will decide the dose of ReFacto that is best for you. Doctors determine doses for all factor VIII products by using a specific formula. For bleeding, the formula uses your weight, the location and severity of your bleeding, and the amount of factor in your blood to calculate the right dose.36 For short-term routine prophylaxis, your doctor determines your dose based on your weight and the desired dosing frequency.

Your doctor may decide to change the dose of ReFacto during treatment; for example, a change may be necessary if your weight changes, you have surgery, or you develop an inhibitor.

What is in each carton of ReFacto?
Each carton of ReFacto is color-coded so you can easily know which dose is contained inside. The carton will contain a single-use vial of 250, 500, 1000, or 2000 IU, a vial adapter, a sterile syringe prefilled with the diluent you will need for reconstitution, one sterile infusion set, and alcohol swabs.

How do I reconstitute ReFacto?
Always wash your hands before preparing for reconstitution. Aseptic (germ-free) technique should be used during the reconstitution procedure.

ReFacto is administered by intravenous (IV) infusion after reconstitution with the supplied sodium chloride diluent.

To see how to reconstitute ReFacto, click here.

Indication
ReFacto is indicated for the control and prevention of hemorrhagic episodes and for surgical prophylaxis and for short-term routine prophylaxis to reduce the frequency of spontaneous bleeding episodes in patients with hemophilia A. The effect of regular routine prophylaxis on long-term morbidity and mortality is unknown.

Important Safety Information

	•	As with the intravenous administration of any protein product, adverse reactions may include headache, fever, chills, flushing, nausea, vomiting, tiredness, or symptoms of allergic reactions.
	•	The remote possibility exists for hypersensitivity to non-human mammalian proteins. Known hypersensitivity to mouse or hamster proteins may be a contraindication to the use of ReFacto.
	•	Allergic reactions such as hives, itching, difficulty breathing, rapid heart rate, light-headedness and anaphylaxis have been reported for all factor VIII products. Patients should discontinue use of the product and contact their health care provider immediately and/or seek emergency care if any of these symptoms occur.

Please see ReFacto Prescribing Information

The health information contained herein is provided for educational purposes only and is not meant to replace personal discussions between health care providers and patients. All decisions about patient care must be made with a health care provider who can assess the special needs of each individual patient.