The A to B of hemophilia and hemophilia treatment
WHAT IS HEMOPHILIA?
Hemophilia is a type of bleeding disorder that causes the blood to take a long time to [clot]. This can cause abnormal bleeding, or bleeding that won't stop. People with hemophilia have too little—or even none—of a protein in the blood called [clotting factor]. Hemophilia most often affects males and, in most cases, is inherited (passed down through families).
Originally, hemophilia was thought to be a single disease. In the 1950s, health care providers discovered that there are actually two forms of the disease: [hemophilia A] and [hemophilia B]. Because of this, each disease is treated with its own specific factor replacement medication.
HEMOPHILIA A & B:
WHAT IS HEMOPHILIA A OR FACTOR VIII DEFICIENCY?
[Hemophilia A] is the most common form of hemophilia, occurring in about 1 in every
Hemophilia is classified as mild, moderate, or severe, depending on the level of [clotting factor] in the blood. While more severe hemophilia is usually diagnosed during infancy, a mild form may not be diagnosed until adulthood.
People without hemophilia normally have a range of factor VIII or IX that varies from 50% to 150%.
Treating hemophilia A
It's important to manage [hemophilia A] by taking steps to stop bleeds as soon as they start. There are several therapies available to treat [hemophilia A]. Xyntha® Antihemophilic Factor (Recombinant), Plasma/Albumin-Free is a factor VIII replacement product made using a process called [recombinant factor] technology, meaning that it is not made using donated human blood. XYNTHA is also purified using a state-of-the-art process that is free from human or added animal materials* to reduce the risk of viral contamination. XYNTHA® SOLOFUSE® is the only all-in-one reconstitution device for hemophilia A patients, and it comes with:
- Demonstrated bleed control on demand and before and after surgery in clinical trials
- All-in-one reconstitution, which means no more transfer step and no more vials
- A range of dosing options—250, 500, 1000, 2000, and 3000 IU
- Low 4-mL diluent
- An all-inclusive kit that is ready to go when you are
- XYNTHA is manufactured using Chinese hamster ovary (CHO) cells from a master cell bank. These cells are grown in an albumin-free culture. XYNTHA contains trace amounts of hamster protein. You may develop an allergic reaction to these proteins. Tell your doctor if you have had an allergic reaction to hamster protein.
Visit XYNTHA.com to learn more, and watch XYNTHA SOLOFUSE in action.
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WHAT IS HEMOPHILIA B OR FACTOR IX DEFICIENCY?
People with [hemophilia B] have a deficiency in clotting [factor IX]. [Hemophilia B] is sometimes called [Christmas disease] after Stephen Christmas, the first patient described with this disease. It is the second most common form of hemophilia, occurring in about 1 in 20,000-50,000 people.
Treating hemophilia B
It's important to manage [hemophilia B] by taking steps to stop bleeds as soon as they start. There are several therapies available to treat [hemophilia B]. One of these is made using [recombinant factor] technology, meaning that it is made in genetically engineered cells. It's called BeneFix® Coagulation Factor IX (Recombinant), and it has more than 15 years of clinical experience.† BeneFix is designed with viral safety in mind. With BeneFix you get:
- A demonstrated safety record for more than 15 years†
- Established bleed control across a wide range of hemophilia B patients
- Simple reconstitution and a range of doses—including the first 3000-IU dose for hemophilia B patients—all with a low 5-mL diluent
- Enhanced room temperature storage or under refrigeration (2°C to 30°C/36°F to 86°F) for up to 2 years until expiration
To find the most up-to-date information about BeneFix, visit BeneFix.com.
For a comprehensive look at hemophilia B and its treatment, as well as what to expect while living with or caring for someone with hemophilia B, you can download "Living with hemophilia B."
†BeneFix was approved February 11, 1997.
GET STARTED ON XYNTHA OR BENEFIX WITH THE PFIZER TRIAL PRESCRIPTION PROGRAM:
Eligible patients can receive a one-time, 1-month supply up to 20,000 IU of Pfizer factor product at no cost.‡
‡Terms and Conditions apply.
HOW IS HEMOPHILIA INHERITED?
Hemophilia is an X-linked genetic disorder. The infographic below helps explain how inherited genes play a role.
The signs and symptoms of hemophilia can include:
- Bleeding following injury
- [Spontaneous bleeding] (spontaneous means that the bleeding occurs without an apparent cause)
- Pain and swelling resulting from bleeding into joints and muscles
- Blood in the urine or stool
- Heavy bleeding following circumcision
- Unexplained nosebleeds
- Brain bleeds